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      中醫中藥

      支原體肺炎患兒應用小兒豉翹清熱顆粒聯合阿奇霉素治療的觀察

      趙男

      [文章下載]

      【摘要】  【摘要】目的 探討支原體肺炎患兒應用小兒豉翹清熱顆粒聯合阿奇霉素治療的效果。方法 選擇我院100例2017年6月至2018年1月支原體肺炎患兒。隨機分組,阿奇霉素組采取阿奇霉素治療,中西醫藥物聯合治療組則采取阿奇霉素聯合小兒豉翹清熱顆粒治療。比較兩組支原體肺炎療效;炎癥因子恢復正常的時間、咳嗽癥狀消失時間、喘息消失時間、發熱消失時間;治療前后患兒第一秒用力呼氣容積、最大呼氣流量、肺活量、腫瘤壞死因子-α、C反應蛋白;不良反應。

      【關鍵字】  支原體肺炎,小兒豉翹清熱顆粒,阿奇霉素,治療效果

      中圖分類號:文獻標識碼:文章編號:

      [Abstract]Objective To investigate the effect of Xiaoerqin Qingre Granule combined with Xiaoerchiqiaoqingrekeli in children with mycoplasmal pneumonia. Methods 100 children with mycoplasma pneumonia from June 2017 to January 2018 were enrolled in our hospital. Randomly, the Xiaoerchiqiaoqingrekeli group was treated with Xiaoerchiqiaoqingrekeli, and the combination of Chinese and Western medicine was treated with Xiaoerchiqiaoqingrekeli combined with Xiaoerchiqiaoqingrekeli Granule. Comparison of the efficacy of mycoplasmal pneumonia in two groups; time to return to normal inflammatory factors, time to disappear cough symptoms, time to disappear from wheezing, time to disappear from fever; forced expiratory volume in the first second before and after treatment, maximum expiratory flow, vital capacity, tumor necrosis factor- α, C-reactive protein; adverse reactions. Results The efficacy of mycoplasmal pneumonia in the combined treatment group of Chinese and Western medicine, the time when inflammatory factors returned to normal, the time of disappearance of cough symptoms, the time of disappearance of wheezing, the time of disappearance of fever, the forced expiratory volume in the first second, the maximum expiratory flow, vital capacity, tumor necrosis factor-α, C-reactive protein was better than the Xiaoerchiqiaoqingrekeli group, P<0.05. The adverse reactions of the combination of Chinese and Western medicine in the treatment group were less than those in the Xiaoerchiqiaoqingrekeli group. Conclusion Xiaoerchiqiaoqingrekeli Granule combined with Xiaoerchiqiaoqingrekeli is effective in treating mycoplasmal pneumonia, which can effectively improve symptoms and lung function, control inflammation index, and no serious adverse reactions.

      支原體肺炎在兒童中發病率很高,在臨床實踐中更為常見,對兒童的生活質量有很大影響。有針對性地使用抗生素是改善癥狀和促進康復的重要措施。但單一抗生素治療效果有限[1]。本研究選擇我院100例2017年6月至2018年1月支原體肺炎患兒。隨機分組,阿奇霉素組采取阿奇霉素治療,中西醫藥物聯合治療組則采取阿奇霉素聯合小兒豉翹清熱顆粒治療。比較兩組支原體肺炎療效;炎癥因子恢復正常的時間、咳嗽癥狀消失時間、喘息消失時間、發熱消失時間;治療前后患兒第一秒用力呼氣容積、最大呼氣流量、肺活量、腫瘤壞死因子-α、C反應蛋白;不良反應,分析了支原體肺炎患兒應用小兒豉翹清熱顆粒聯合阿奇霉素治療的效果,報道如下。 1 資料與方法 1.1 一般資料:選擇我院100例2017年6月至2018年1月支原體肺炎患兒。隨機分組,其中,阿奇霉素組年齡2~11(6.15±2.12)歲。男女分別35例和15例。支原體肺炎病程2~12 d,平均(5.91±0.55)d。中西醫藥物聯合治療組年齡2-12(6.14±2.71)歲。男女分別34例和16例。支原體肺炎病程2~11 d,平均(5.67±0.67)d。阿奇霉素組、中西醫藥物聯合治療組資料有可比性。 1.2 方法:阿奇霉素組采取阿奇霉素治療,阿奇霉素劑量是10 mg/(kg?d),將其混合250 mL生理鹽水緩慢靜滴,每天1次,用藥第五天停止治療,再過4 d按照10 mg/kg口服,每天2次,治療2周。中西醫藥物聯合治療組則采取阿奇霉素聯合小兒豉翹清熱顆粒治療。小兒豉翹清熱顆粒劑量是1 g,每天3次,沖溫水服用,治療2周。 1.3 指標:比較兩組支原體肺炎療效;炎癥因子恢復正常的時間、咳嗽癥狀消失時間、喘息消失時間、發熱消失時間;治療前后患兒第一秒用力呼氣容積、最大呼氣流量、肺活量、腫瘤壞死因子-α、C反應蛋白;不良反應。顯效:第一秒用力呼氣容積、最大呼氣流量、肺活量、腫瘤壞死因子-α、C反應蛋白復常,咳嗽、發熱和喘息等癥狀體征消失;有效:第一秒用力呼氣容積、最大呼氣流量、肺活量、腫瘤壞死因子-α、C反應蛋白、咳嗽、發熱和喘息等癥狀體征改善一半以上;無效:第一秒用力呼氣容積、最大呼氣流量、肺活量、腫瘤壞死因子-α、C反應蛋白改善的程度低于50%。療效=顯效、有效百分率之和[2]。 1.4 統計學處理:SPSS16.0軟件進行數據處理,計量數據進行t檢驗,計數數據進行χ2檢驗,P<0.05說明有統計學意義。

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