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      中醫中藥

      四君子湯加減聯合腸內營養對胃癌術后患者免疫功能的影響

      李月紅

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      【摘要】  【摘要】目的 探討評價四君子湯加減聯合腸內營養對胃癌術后患者免疫功能的影響。方法:選擇我院2017年11月至2019年2月內收診的110例胃癌患者作為對象,采用隨機數表法按照1∶1比例將其分成對照組和研究組,各組占55例,對照組單純給予腸內營養治療,研究組則給予腸內營養+四君子湯加減治療,觀察兩組患者術后恢復情況,并比較術前與術后的免疫功能。

      【關鍵字】  四君子湯加減,腸內營養,胃癌,術后,免疫功能

      中圖分類號:文獻標識碼:文章編號:

      [Abstract] Objective To evaluate the effect of Sijunzi Decoction plus enteral nutrition on immune function in patients with gastric cancer after operation. Methods 110 patients with gastric cancer admitted to our hospital from November 2017 to February 2019 were selected as subjects and randomly divided into control group and research group according to the ratio of 1∶1. Each group accounted for 55 cases. The control group was treated with enteral nutrition alone, while the research group was treated with enteral nutrition plus Sijunzi decoction. The recovery of patients in the two groups was observed and the preoperative and postoperative exemptions were compared. Epidemic function. Results Firstly, the exhaust time and hospitalization time of the study group were shorter than those of the control group, the difference was significant (P<0.05), but there was no significant difference in defecation time between the two groups (P>0.05). Secondly, there was no significant difference in IgG, IgA, CD4+, CD8+, CD4+/CD8+ between the two groups before operation (P>0.05), and the indexes of the two groups increased 10 days after operation. The IgG, IgA, CD4+, CD4+/CD8+ in the study group were higher than those in the control group, with significant difference (P<0.05). Conclusion Sijunzi Decoction combined with enteral nutrition can promote the recovery of patients with gastric cancer and improve the immune function, which is worthy of promotion and reference.

      胃癌是床常見惡性腫瘤,發病率高,早期缺乏典型癥狀,多數病患確診時已經發展至晚期,多采取手術切除方法治療。然而,胃是人體重要的消化器官,胃部發生惡性腫瘤直接影響正常進食及消化,甚至引起消化不良[1]。手術切除后,由于應激反應,可能增加機體分解及代謝,導致營養不良程度加重,降低免疫功能,引起并發癥,預后欠佳[2]。因此,胃癌術后應該加強營養干預,促進患者早日康復。本文筆者為了探討觀察四君子湯加減聯合腸內營養對胃癌術后患者免疫功能的影響,選擇2017年11月至2019年2月內收診的110例患者且分成兩組進行研究,取得了滿意效果,現在將方法及結果總結報道如下。 1 資料與方法 1.1 一般資料:選擇我院2017年11月至2019年2月內收診的110例胃癌患者作為對象,采用隨機數表法按照1∶1比例將其分成對照組和研究組,各組占55例。納入標準:①所有病例符合《胃癌診斷標準》[3]中關于胃癌的診斷標準;②行胃癌根治術治療患者;③符合Konsman等[4]制定的關于臨床營養不良的診斷標準;④入院前3個月,體質量降低>5%,或者TRF水平<2.0 g/L,或者白蛋白水平<35 g/L;⑤年齡20~70歲,性別不限;⑥自愿參與研究并簽署有知情同意書。排除標準:①不愿參與本次研究者;②年齡>70歲,或者年齡<20歲的患者;③合并有心肝腎等嚴重臟器功能不全患者;④免疫缺陷患者;⑤合并有代謝性疾病或者感染性疾病患者;⑥術中發現存在遠端轉移,無法行根治術的患者;⑦接受過放化療治療的患者;⑧妊娠期或者哺乳期女性;⑨認知障礙、精神障礙患者;⑩失語失聰、無法正常交流的患者。對照組55例患者中包括29例男性和26例女性,最小24歲,最大67歲,平均年齡(42.93±5.48)歲。研究組55例患者中包括31例男性和24例女性,最小23歲,最大69歲,平均年齡(41.27±5.62)歲。數據分析發現,研究組與對照組性別及年齡等基線資料并無明顯差異,P>0.05,可分組討論。

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